Here's how I am setting my weekly 4 inch squares. I decided to set them into a grid structure separated by one inch sashing into rows of four. After the year passes I will have a quilt top of 4 by 13 rows, a total of 52 blocks for the 52 weeks of the year. Doing it now as I go along each week is better than waiting till the end.
This allows me to improve the design of the overall quilt as I go along because I can see how the blocks are interacting and plan my future blocks to fit in with the colors and design of what is already in place. I also noticed that I am aware of the passage of time simply by looking at how many blocks I have done. Besides, I won't have little squares lying around with the potential for getting misplaced. After the year is done, I will layer the top with a thin batting or felt or wool or flannel, add backing, and hold the piece together by quilting on the sashing. Sounds like a plan to me!